Model Informed Drug Development Archives

Publication

Ximelagatran, an oral direct thrombin inhibitor, is rapidly bioconverted to melagatran, its active form. The…

webdevJanuary 1, 2003

Publication

This paper presents and illustrates methodology for specifying, estimating, and evaluating a predictive model for…

webdevDecember 1, 1999

Publication

Urinary drug metabolite ratios and urinary recoveries of metabolites, have been used to assess specific…

webdevJune 1, 1999

Publication

Probe substrates for various isoforms of cytochrome P450 and other drug-metabolizing enzymes are now widely…

webdevDecember 1, 1998

Publication

At least six urinary metabolite ratios of caffeine have been proposed as probes for in…

webdevApril 1, 1996

Model Informed Drug Development