Simcyp Discovery is a versatile tool designed to enhance decision-making during the pre-IND and translational stages of drug development. By leveraging physiologically-based pharmacokinetic (PBPK) modeling, this software enables researchers to answer critical “what if” questions without the need for costly and time-consuming clinical studies. Derived from the gold-standard Simcyp PBPK Simulator, Simcyp Discovery accelerates small molecule discovery and development, providing confidence in early-stage decision-making.
Simcyp™ Discovery
Innovative PBPK software that supports screening, first-in-human dose prediction, early DDI and formulation decisions
Transform your pre-IND process with Simcyp Discovery
Mechanistic first-in-human dose prediction.
Compound triage and pipeline optimization.
Early formulation simulation.
Drug-drug interaction screening.
Translation from preclinical species to human PK.
Allow a better understanding of the PK/PD relationship earlier in development process.
Key features of Simcyp Discovery
Simcyp Discovery includes PBPK models for human, mouse, rat, dog, and monkey. It provides a range of model and simulation tools tailored for discovery and translational scientists.
Variety of models included
- Minimal and full PBPK models.
- One-, two-, and three-compartment models.
- First order (FO) and Advanced Dissolution, Absorption, and Metabolism (ADAM) PBPK models.
- Ability to model rat, mouse, monkey, dog, and human in one modeling environment.
DDI calculator
- Quickly flags early DDI risk for enzymes and transporters based on published regulatory guidance.
- Includes basic (cut-off) models, including competitive inhibition, mechanism-based inhibition, induction, transporter inhibition, and mechanistic static interaction models.
Sensitivity analysis
- Perform different sensitivity analyses using the automated sensitivity analysis tool.
- Utilize sensitivity analysis for formulation development to determine what is needed to improve the formulation, such as increasing solubility using a spray-dried dispersion formulation or reducing particle size via micronisation.
Estimate PK parameters
- Estimation of PK parameters from the in vivo data for the reference formulation (i.e. IV, oral solution, etc.).
Benefits of using Simcyp Discovery
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Experience the power of Simcyp Discovery. Schedule a demo to see how Simcyp Discovery can transform your pre-IND drug development process.
Gain confidence in early-stage decision-making.
Accelerate lead compound identification with high-throughput screening.
Predict first-in-human pharmacokinetics with precision.
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Simcyp Discovery FAQs
What is Simcyp Discovery PBPK software?
Simcyp Discovery is a physiologically-based pharmacokinetic (PBPK) software designed to enhance decision-making during pre-IND drug development.
How does Simcyp Discovery support first-in-human studies?
Simcyp Discovery uses PBPK and IVIVE to predict pharmacokinetics and dosing for first-in-human studies.
Can Simcyp Discovery be used for formulation screening?
Yes, Simcyp Discovery supports early formulation screening to optimize solubility, particle size, and other critical factors.
